Article

The PRC2-dependent epigenetic reprograming of the bladder epithelium exacerbates urinary tract infections

2020-10-22

Abstract excerpt

Mucosal imprint sensitizes recurrent urinary tract infections (UTIs), a significant health and quality of life burden worldwide, which are associated with heightened inflammatory host response, severe basal cell hyperplasia and impaired superficial cell differentiation. Here, we show that bladder infections induce expression of Ezh2 , the methyltransferase of polycomb repressor complex 2 (PRC2)-dependent epigenet...

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Literature Corpus work: 3600cb8f-0c8d-53ce-821b-11927a151833
DOI: 10.1101/2020.10.22.350942

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