Article
Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.
PLoS genetics - 1 Aug 2016
Sun Wei, Kechris Katerina, Jacobson Sean, Drummond M Bradley, Hawkins Gregory A, Yang Jenny, Chen Ting-Huei, Quibrera Pedro Miguel, Anderson Wayne, Barr R Graham, Basta Patricia V, Bleecker Eugene R, Beaty Terri, Casaburi Richard, Castaldi Peter, Cho Michael H, Comellas Alejandro, Crapo James D, Criner Gerard, Demeo Dawn, Christenson Stephanie A, Couper David J, Curtis Jeffrey L, Doerschuk Claire M, Freeman Christine M, Gouskova Natalia A, Han MeiLan K, Hanania Nicola A, Hansel Nadia N, Hersh Craig P, Hoffman Eric A, Kaner Robert J, Kanner Richard E, Kleerup Eric C, Lutz Sharon, Martinez Fernando J, Meyers Deborah A, Peters Stephen P, Regan Elizabeth A, Rennard Stephen I, Scholand Mary Beth, Silverman Edwin K, Woodruff Prescott G, O'Neal Wanda K, Bowler Russell P
Abstract excerpt
Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental variations contribute to phenotypic diversity and disease progression. A meta-analysis from two large cohorts of current and former smokers with and without COPD [SPIROMICS (N = 750); COPDGene (N =...
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