Article
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine - 15 Dec 2012
Kim Deog Kyeom, Cho Michael H, Hersh Craig P, Lomas David A, Miller Bruce E, Kong Xiangyang, Bakke Per, Gulsvik Amund, Agustí Alvar, Wouters Emiel, Celli Bartolome, Coxson Harvey, Vestbo Jørgen, MacNee William, Yates Julie C, Rennard Stephen, Litonjua Augusto, Qiu Weiliang, Beaty Terri H, Crapo James D, Riley John H, Tal-Singer Ruth, Silverman Edwin K
Abstract excerpt
RATIONALE: A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility. OBJECTIVES: To identify genetic variants of circulating protein biomarkers and novel genetic determinants of COPD. METHODS: GWAS was performed for two pneumoproteins, Clara cell secretory protein (CC16) and...
Topics
- C-Reactive Protein
- Female
- Fibrinogen
- Genetic Markers
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Interleukin-6