Article
Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation.
The European respiratory journal - 1 Nov 2017
Obeidat Ma'en, Li Xuan, Burgess Stephen, Zhou Guohai, Fishbane Nick, Hansel Nadia N, Bossé Yohan, Joubert Philippe, Hao Ke, Nickle David C, van den Berge Maarten, Timens Wim, Cho Michael H, Hobbs Brian D, de Jong Kim, Boezen Marike, Hung Rayjean J, Rafaels Nicholas, Mathias Rasika, Ruczinski Ingo, Beaty Terri H, Barnes Kathleen C, Paré Peter D, Sin Don D
Abstract excerpt
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.In 4061 subjects with COPD, we identified genetic variants associated with serum SP-D levels. We then determined whether these...
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