Article
Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects.
American journal of respiratory cell and molecular biology - 1 Jul 2017
Busch Robert, Hobbs Brian D, Zhou Jin, Castaldi Peter J, McGeachie Michael J, Hardin Megan E, Hawrylkiewicz Iwona, Sliwinski Pawel, Yim Jae-Joon, Kim Woo Jin, Kim Deog K, Agusti Alvar, Make Barry J, Crapo James D, Calverley Peter M, Donner Claudio F, Lomas David A, Wouters Emiel F, Vestbo Jørgen, Tal-Singer Ruth, Bakke Per, Gulsvik Amund, Litonjua Augusto A, Sparrow David, Paré Peter D, Levy Robert D, Rennard Stephen I, Beaty Terri H, Hokanson John, Silverman Edwin K, Cho Michael H
Abstract excerpt
The heritability of chronic obstructive pulmonary disease (COPD) cannot be fully explained by recognized genetic risk factors identified as achieving genome-wide significance. In addition, the combined contribution of genetic variation to COPD risk has not been fully explored. We sought to determine: (1) whether studies of variants from previous studies of COPD or lung function in a larger sample could identify...
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