Article
A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma.
Oncotarget - 20 Sept 2016
Krook Melanie A, Hawkins Allegra G, Patel Rajiv M, Lucas David R, Van Noord Raelene, Chugh Rashmi, Lawlor Elizabeth R
Abstract excerpt
Tumor heterogeneity is a major impediment to cancer cures. Tumor cell heterogeneity can arise by irreversible genetic mutation, as well as by non-mutational mechanisms, which can be reversibly modulated by the tumor microenvironment and the epigenome. We recently reported that the chemokine receptor CXCR4 is induced in Ewing sarcoma cells in response to microenvironmental stress. In the current study, we...
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