Article

Intratumoral Heterogeneity of Vimentin Modulates Nuclear Mechanotransduction, DNA Damage Response and Cancer Cell Survival

2025-06-28

Abstract excerpt

Vimentin, a major intermediate filament protein, is essential for maintaining cellular integrity and regulating cytoskeletal dynamics. Its upregulation is a hallmark of epithelial-to-mesenchymal transition (EMT), a process that enhances cancer cell migration, invasion, and metastatic potential. However, single-cell transcriptomic analyses of glioblastoma, the most common and aggressive primary brain tumor, reveal...

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Literature Corpus work: 6406a03d-67b9-5f63-8ea1-b51cab9b86db
DOI: 10.1101/2025.06.27.661506

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