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Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression

25 Mar 2022

Abstract excerpt

Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent years has further established diagnostic as well as prognostic importance of CXCR4 signaling. CXCR4 and SDF-1 are routinely reported to be elevated in tumors, distant metastases, which correlates...

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PMID: 35346802
DOI: 10.1016/j.semcancer.2022.03.019

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