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Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

2025-06-24

Abstract excerpt

Ewing sarcoma (EwS) is a fusion-driven malignancy, peaking in adolescence. Although EwS tumors are driven uniquely by EWS::FLI1 and related fusions, patient outcomes vary greatly. If and how tumor plasticity of EWS::FLI1-regulated transcriptional signatures contribute to disease progression is not known. To address this, we utilized a single-cell co-assay of RNA and chromatin accessibility (ATAC) sequencing to ide...

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Literature Corpus work
64ed4f0c-4000-5ab7-8fc6-fbd5f127bf72
DOI
10.1101/2025.06.18.660457
Open publication

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Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcomaDOI 10.1101/2025.06.18.660457
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