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Article

EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma

2 Jun 2022

Abstract excerpt

PURPOSE: Propagation of Ewing sarcoma requires precise regulation of EWS::FLI1 transcriptional activity. Determining the mechanisms of fusion regulation will advance our understanding of tumor progression. Here we investigated whether HOXD13, a developmental transcription factor that promotes Ewing sarcoma metastatic phenotypes, influences EWS::FLI1 transcriptional activity. EXPERIMENTAL DESIGN: Existing tumor...

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PMID: 35653119
DOI: 10.1158/1078-0432.ccr-22-0384

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