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Article

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

2021-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or highly related fusions. EWS/FLI dysregulates transcription to induce and maintain sarcomagenesis, but the mechanisms utilized are not fully understood. We therefore sought to define the global effects of EWS/FLI on chromatin conformation and transcription in Ewing sarcoma. We found t...

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Literature Corpus work
eea892db-ffe4-5b4c-8f57-4a3c09002eed
DOI
10.1101/2021.09.30.462658
Open publication

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EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcomaDOI 10.1101/2021.09.30.462658
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