Article
A reciprocal feedback loop between HIF-1α and HPIP controls phenotypic plasticity in breast cancer cells.
Cancer letters - 1 Feb 2022
Khumukcham Saratchandra Singh, Penugurti Vasudevarao, Soni Anita, Uppala Veena, Hari Kishore, Jolly Mohit Kumar, Dwivedi Anju, Salam Pk Abdul, Padala Chiranjeevi, Mukta Srinivasulu, Bhopal Triveni, Manavathi Bramanandam
Abstract excerpt
While phenotypic plasticity is a critical factor contributing to tumor heterogeneity, molecular mechanisms underlying this process are largely unknown. Here we report that breast cancer cells display phenotypic diversity in response to hypoxia or normoxia microenvironments by operating a reciprocal positive feedback regulation of HPIP and HIF-1α. We show that under hypoxia, HIF-1α induces HPIP expression that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.