Article
Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases.
Genetics - 1 Oct 2016
Rössl Anthony, Bentley-DeSousa Amanda, Tseng Yi-Chieh, Nwosu Christine, Downey Michael
Abstract excerpt
Nicotinamide is both a reaction product and an inhibitor of the conserved sirtuin family of deacetylases, which have been implicated in a broad range of cellular functions in eukaryotes from yeast to humans. Phenotypes observed following treatment with nicotinamide are most often assumed to stem from inhibition of one or more of these enzymes. Here, we used this small molecule to inhibit multiple sirtuins at once...
Topics
- DNA Damage
- Gene Expression Regulation, Fungal
- Gene Silencing
- Group III Histone Deacetylases
- Methyl Methanesulfonate
- Niacinamide
- Nicotinamidase
- Phenotype
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sirtuins