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Article

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs.

Biochimica et biophysica acta - 1 Oct 1998

Reid R J, Benedetti P, Bjornsti M A

Abstract excerpt

The budding yeast Saccharomyces cerevisiae has been exploited to investigate the cytotoxic mechanisms of drugs that target DNA topoisomerases. This model organism has been used to establish eukaryotic DNA topoisomerase I or II as the cellular target of specific antineoplastic agents, to define mutations in these enzymes that confer drug resistance and to elucidate the cellular factors that modulate cell...

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Identifiers

PMID: 9748633
DOI: 10.1016/s0167-4781(98)00142-0

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Source receipt: pubmed, retrieved 7 Sept 2026.

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