Article
Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs.
Biochimica et biophysica acta - 1 Oct 1998
Reid R J, Benedetti P, Bjornsti M A
Abstract excerpt
The budding yeast Saccharomyces cerevisiae has been exploited to investigate the cytotoxic mechanisms of drugs that target DNA topoisomerases. This model organism has been used to establish eukaryotic DNA topoisomerase I or II as the cellular target of specific antineoplastic agents, to define mu...
Topics
- Antineoplastic Agents
- Cell Death
- DNA Damage
- DNA Topoisomerases, Type I
- Drug Resistance
- Enzyme Inhibitors
- Mutation
- Saccharomyces cerevisiae
- Topoisomerase I Inhibitors
- Topoisomerase II Inhibitors