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Article

Sirtuins in yeast: phenotypes and tools.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Tsuchiyama Scott, Kwan Elizabeth, Dang Weiwei, Bedalov Antonio, Kennedy Brian K

Abstract excerpt

Originally discovered as a transcriptional silencing protein, SIR2 was later linked to yeast replicative aging and the rest was history. Sir2p is now known to be a member of a class of protein deacetylases with a unique enzymatic activity coupling the deacetylation event to NAD(+) hydrolysis. While still incompletely understood, the mechanism by which Sir2p modulates yeast aging is linked to inhibition of rDNA...

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PMID: 24014397
DOI: 10.1007/978-1-62703-637-5_2

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