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Article

Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae.

Genetics - 1 Aug 2008

Cejka Petr, Jiricny Josef

Abstract excerpt

Methylating agents of S(N)1 type are widely used in cancer chemotherapy, but their mode of action is poorly understood. In particular, it is unclear how the primary cytotoxic lesion, O(6)-methylguanine ((Me)G), causes cell death. One hypothesis stipulates that binding of mismatch repair (MMR) proteins to (Me)G/T mispairs arising during DNA replication triggers cell-cycle arrest and cell death. An alternative...

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Identifiers

PMID: 18579505
DOI: 10.1534/genetics.108.089979
PMCID: PMC2516062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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