Sirtuins in Epigenetic Silencing and Control of Gene Expression in Model and Pathogenic Fungi

Abstract excerpt

Fungi, including yeasts, molds, and mushrooms, proliferate on decaying matter and then adopt quiescent forms once nutrients are depleted. This review explores how fungi use sirtuin deacetylases to sense and respond appropriately to changing nutrients. Because sirtuins are NAD + -dependent deacetylases, their activity is sensitive to intracellular NAD + availability. This allows them to transmit information about...

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