Article
Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics.
eLife - 12 Nov 2013
Zhou Keming, Stawicki Tamara M, Goncharov Alexandr, Jin Yishi
Abstract excerpt
The presynaptic active zone proteins UNC-13/Munc13s are essential for synaptic vesicle (SV) exocytosis by directly interacting with SV fusion apparatus. An open question is how their association with active zones, hence their position to Ca(2+) entry sites, regulates SV release. The N-termini of major UNC-13/Munc13 isoforms contain a non-calcium binding C2A domain that mediates protein homo- or hetero-meric...
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