Article
Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.
Neuroscience letters - 19 Sept 2016
Przybyla Magdalena, Stevens Claire H, van der Hoven Julia, Harasta Anne, Bi Mian, Ittner Arne, van Hummel Annika, Hodges John R, Piguet Olivier, Karl Tim, Kassiou Michael, Housley Gary D, Ke Yazi D, Ittner Lars M, van Eersel Janet
Abstract excerpt
Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and...
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