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Article

Hyperactivity with Agitative-Like Behavior in a Mouse Tauopathy Model.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Jul Pia, Volbracht Christiane, de Jong Inge E M, Helboe Lone, Elvang Anders Brandt, Pedersen Jan Torleif

Abstract excerpt

Tauopathies, such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau. In addition to memory loss, patients experience behavioral symptoms such as agitation, aggression, depression, and insomnia. We explored the behavioral phenotype of a mouse model (rTg4510) carrying the human tau P301L mutation found in a...

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Identifiers

PMID: 26519432
DOI: 10.3233/JAD-150292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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