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Article

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia.

Neurobiology of aging - 1 Jul 2014

Cook Casey, Dunmore Judy H, Murray Melissa E, Scheffel Kristyn, Shukoor Nawsheen, Tong Jimei, Castanedes-Casey Monica, Phillips Virginia, Rousseau Linda, Penuliar Michael S, Kurti Aishe, Dickson Dennis W, Petrucelli Leonard, Fryer John D

Abstract excerpt

Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is a neurodegenerative tauopathy caused by mutations in the tau gene (MAPT). Individuals with FTDP-17 have deficits in learning, memory, and language, in addition to personality and behavioral changes that are often characterized by a lack of social inhibition. Several transgenic mouse models expressing tau mutations have been tested...

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Source

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Identifiers

PMID: 24503275
DOI: 10.1016/j.neurobiolaging.2013.12.023
PMCID: PMC3992979

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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