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Article

APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).

Neuroscience and biobehavioral reviews - 1 May 2012

Lalonde R, Fukuchi K, Strazielle C

Abstract excerpt

The discovery of gene mutations responsible for autosomal dominant Alzheimer's disease has enabled researchers to reproduce in transgenic mice several hallmarks of this disorder, notably Aβ accumulation, though in most cases without neurofibrillary tangles. Mice expressing mutated and wild-type APP as well as C-terminal fragments of APP exhibit variations in exploratory activity reminiscent of behavioural and...

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Identifiers

PMID: 22373961
DOI: 10.1016/j.neubiorev.2012.02.011
PMCID: PMC3340431

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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