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Sexual dimorphism in behavior, neuropathology, and biomarkers in a tau P301S mouse model of Alzheimer’s disease

2019-11-11

Abstract excerpt

Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD. To elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic approaches targeting tau, numerous transgenic mouse models that recapitulate critical AD-like pathology have been developed. Tau P301S tra...

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Literature Corpus work
ac207303-480d-593b-bc6c-b5c5d4dc99ad
DOI
10.21203/rs.2.17109/v1
Open publication

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Sexual dimorphism in behavior, neuropathology, and biomarkers in a tau P301S mouse model of Alzheimer’s diseaseDOI 10.21203/rs.2.17109/v1
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