Article
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Neurobiology of learning and memory - 1 Apr 2016
Van der Jeugd Ann, Vermaercke Ben, Halliday Glenda M, Staufenbiel Matthias, Götz Jürgen
Abstract excerpt
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder, a major subset of which is characterized by the accumulation of abnormal forms of the protein tau, leading to impairments in motor functions as well as language and behavioral alterations. Tau58-2/B mice express human tau with the P301S mutation found in familial forms of FTLD in neurons. By assessing three age cohorts of Tau58-2/B mice in...
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