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Article

The differential impact of natural killer (NK) cell education via KIR2DL3 and KIR3DL1 on CCL4 secretion in the context of in-vitro HIV infection.

Clinical and experimental immunology - 1 Dec 2016

Lisovsky I, Isitman G, Tremblay-McLean A, Song R, DaFonseca S, Lebouchẻ B, Routy J-P, Bruneau J, Bernard N F

Abstract excerpt

Carriage of certain inhibitory natural killer (NK) cell receptor (iNKR)/HLA ligand pairs is associated with protection from infection and slow time to AIDS implicating NK cells in HIV control. NK cells acquire functional potential through education, which requires the engagement of iNKRs by their human leucocyte antigen (HLA) ligands. HIV infection down-regulates cell surface HLA-A/B, but not HLA-C/E. We...

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Share to CD4-Positive T-Lymphocytes
Share to Chemokine CCL4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-C Antigens

Share to Killer Cells, Natural

Share to Leukocytes, Mononuclear

Share to Lymphocyte Activation

Share to Receptors, KIR2DL3

Share to Receptors, KIR3DL1

Source

Open in PubMed Open full text

Identifiers

PMID: 27506421
DOI: 10.1111/cei.12849
PMCID: PMC5108064

Genes

CCL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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