Article
HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2010
Boulet Salix, Song Rujun, Kamya Philomena, Bruneau Julie, Shoukry Naglaa H, Tsoukas Christos M, Bernard Nicole F
Abstract excerpt
Epidemiological studies in humans have implicated carriage of combinations of genes encoding certain KIR3DL1 (killer Ig-like receptor 3DL1) alleles and their HLA-Bw4 ligands in slower progression to AIDS, lower viral load and protection from infection. Given that the KIR3DL1*h/*y/HLA-B*57 genetic...
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