Article
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.
Nature genetics - 1 Jun 2007
Martin Maureen P, Qi Ying, Gao Xiaojiang, Yamada Eriko, Martin Jeffrey N, Pereyra Florencia, Colombo Sara, Brown Elizabeth E, Shupert W Lesley, Phair John, Goedert James J, Buchbinder Susan, Kirk Gregory D, Telenti Amalio, Connors Mark, O'Brien Stephen J, Walker Bruce D, Parham Peter, Deeks Steven G, McVicar Daniel W, Carrington Mary
Abstract excerpt
Allotypes of the natural killer (NK) cell receptor KIR3DL1 vary in both NK cell expression patterns and inhibitory capacity upon binding to their ligands, HLA-B Bw4 molecules, present on target cells. Using a sample size of over 1,500 human immunodeficiency virus (HIV)+ individuals, we show that various distinct allelic combinations of the KIR3DL1 and HLA-B loci significantly and strongly influence both AIDS...
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