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The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control

17 Oct 2019

Abstract excerpt

Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections. The killer immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnership in the human genome and govern the process of NK cell education. The KIR and HLA...

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PMID: 31627371
DOI: 10.3390/v11100959

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