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Article

HIV protective KIR3DL1/S1-HLA-B genotypes influence NK cell-mediated inhibition of HIV replication in autologous CD4 targets.

PLoS pathogens - 1 Jan 2014

Song Rujun, Lisovsky Irene, Lebouché Bertrand, Routy Jean-Pierre, Bruneau Julie, Bernard Nicole F

Abstract excerpt

Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobulin-like Receptor (KIR)3DL1 with its ligand, HLA-B*57 (*h/*y+B*57) is associated with slower time to AIDS and better HIV viral load control than being a Bw6 homozygote (Bw6hmz). Natural Killer (NK) cells from *h/*y+B*57 carriers receive potent educational signals through HLA-B*57 KIR3DL1 ligation leading to high functional...

Read the complete abstract on PubMed

Topics

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Share to CD4-Positive T-Lymphocytes
Share to HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to HLA-B Antigens

Share to Immunity, Cellular

Share to Killer Cells, Natural

Share to Receptors, KIR3DL1

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 24453969
DOI: 10.1371/journal.ppat.1003867
PMCID: PMC3894215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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