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Article

M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner.

Journal of leukocyte biology - 1 Jan 2017

Krneta Tamara, Gillgrass Amy, Poznanski Sophie, Chew Marianne, Lee Amanda J, Kolb Martin, Ashkar Ali A

Abstract excerpt

The crosstalk between NK cells and M1 macrophages has a vital role in the protection against infections and tumor development. However, macrophages in the tumor resemble an M2 phenotype, and, at present, their effect on NK cells is less clear. This study investigated whether tumor-associated macrophages (TAMs) have a role in altering NK cell function and phenotype using in vitro cocultures of murine NK cells with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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PMID: 27493241
DOI: 10.1189/jlb.3A1215-552R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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