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Article

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2009

Balsamo Mirna, Scordamaglia Francesca, Pietra Gabriella, Manzini Claudia, Cantoni Claudia, Boitano Monica, Queirolo Paola, Vermi William, Facchetti Fabio, Moretta Alessandro, Moretta Lorenzo, Mingari Maria Cristina, Vitale Massimo

Abstract excerpt

Although the role of the tumor microenvironment in the process of cancer progression has been extensively investigated, the contribution of different stromal components to tumor growth and/or evasion from immune surveillance is still only partially defined. In this study we analyzed fibroblasts derived from metastatic melanomas and provide evidence for their strong immunosuppressive activity. In coculture...

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Identifiers

PMID: 19934056
DOI: 10.1073/pnas.0906481106
PMCID: PMC2791633

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Source receipt: pubmed, retrieved 7 Sept 2026.

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