Article
Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages.
Cancer research - 15 Jan 2013
Liu Ying, Chen Keqiang, Wang Chunyan, Gong Wanghua, Yoshimura Teizo, Liu Mingyong, Wang Ji Ming
Abstract excerpt
FPR2 (Fpr2 in mouse) is a G-protein-coupled receptor interacting with bacterial and host-derived chemotactic agonists. Fpr2 supports innate and adaptive immune responses as illustrated by the reduction in severity of allergic airway inflammation in Fpr2-KO mice, due to impaired trafficking of antigen-presenting dendritic cells (DC). The aim of this study is to examine the role of Fpr2 in host antitumor responses....
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