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Article

Antitumor properties of triptolide: phenotype regulation of macrophage differentiation.

Cancer biology & therapy - 1 Jan 2020

Li Han, Li Liping, Mei Huifang, Pan Guofeng, Wang Xinzhi, Huang Xin, Wang Tao, Jiang Zhenzhou, Zhang Luyong, Sun Lixin

Abstract excerpt

Tumor-associated macrophages (TAMs), which generally exhibit an M2-like phenotype, play a critical role in tumor development. Triptolide exerts a unique bioactive spectrum of anticancer activities. The aim of this study was to determine whether triptolide has any effect on the activation of TAMs and the production of tumor-promoting mediators. ICR-1 mice with azoxymethane/dextran sulfate sodium (AOM/DSS)-induced...

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Identifiers

PMID: 31663424
DOI: 10.1080/15384047.2019.1679555
PMCID: PMC7012063

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