Article
Ia- macrophages and cytokine networks contribute to tumor-induced suppression of CD4+ autoreactive T cells.
Immunological investigations - 1 Apr 1993
Walker T M, Yurochko A D, Burger C J, Elgert K D
Abstract excerpt
Tumor growth changes the functions and phenotypes of macrophages (M phi) and T cells. Suppression of CD4+ T cell autoresponses during tumor growth was contributed primarily by M phi. Tumor-induced alterations in the abilities of these cells to mediate autorecognition were assessed through syngene...
Topics
- Animals
- Antigen-Presenting Cells
- Autoimmunity
- CD4-Positive T-Lymphocytes
- Dinoprostone
- Fibrosarcoma
- Histocompatibility Antigens Class II
- Immunologic Deficiency Syndromes
- Interferon-gamma
- Interleukin-4
- Lymphocyte Culture Test, Mixed