Article
Resistin reinforces interferon λ-3 to eliminate hepatitis C virus with fine-tuning from RETN single-nucleotide polymorphisms.
Scientific reports - 1 Aug 2016
Chang Ming-Ling, Liang Kung-Hao, Ku Cheng-Lung, Lo Chia-Chi, Cheng Ya-Ting, Hsu Chen-Ming, Yeh Chau-Ting, Chiu Cheng-Tang
Abstract excerpt
The effect of resistin (RETN) on the response to anti-HCV therapy remains unclear. A prospective cohort study was performed using 655 consecutive HCV patients, of whom 513 had completed a course of interferon-based therapy. Multivariate and GEE analyses revealed four RETN single-nucleotide polymorphisms (SNPs), rs34861192, rs3219175, rs3745367 and rs1423096, to be synergistically associated with resistin levels....
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