Article
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease.
Nature communications - 5 Mar 2015
Eslam Mohammed, Hashem Ahmed M, Leung Reynold, Romero-Gomez Manuel, Berg Thomas, Dore Gregory J, Chan Henry L K, Irving William L, Sheridan David, Abate Maria L, Adams Leon A, Mangia Alessandra, Weltman Martin, Bugianesi Elisabetta, Spengler Ulrich, Shaker Olfat, Fischer Janett, Mollison Lindsay, Cheng Wendy, Powell Elizabeth, Nattermann Jacob, Riordan Stephen, McLeod Duncan, Armstrong Nicola J, Douglas Mark W, Liddle Christopher, Booth David R, George Jacob, Ahlenstiel Golo
Abstract excerpt
Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.