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Article

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects.

Frontiers in immunology - 1 Jan 2021

Onabajo Olusegun O, Wang Fang, Lee Mei-Hsuan, Florez-Vargas Oscar, Obajemu Adeola, Tanikawa Chizu, Vargas Joselin M, Liao Shu-Fen, Song Ci, Huang Yu-Han, Shen Chen-Yang, Banday A Rouf, O'Brien Thomas R, Hu Zhibin, Matsuda Koichi, Prokunina-Olsson Ludmila

Abstract excerpt

IFNL3/IFNL4 polymorphisms are inversely associated with the risk of chronic hepatitis C virus (HCV) infection and cirrhosis, two major risk factors for developing hepatocellular carcinoma (HCC). To further explore these inverse associations and their molecular underpinnings, we analyzed IFNL3/IFNL4 polymorphisms represented by the IFNL4 genotype (presence of rs368234815-dG or rs12979860-T alleles) in HCV...

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Identifiers

PMID: 34497603
DOI: 10.3389/fimmu.2021.692263
PMCID: PMC8419317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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