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Article

The relationships between IFNL4 genotype, intrahepatic interferon-stimulated gene expression and interferon treatment response differs in HCV-1 compared with HCV-3.

Alimentary pharmacology & therapeutics - 1 Aug 2015

Holmes J A, Congiu M, Bonanzinga S, Sandhu M K, Kia Y H, Bell S J, Nguyen T, Iser D M, Visvanathan K, Sievert W, Bowden D S, Desmond P V, Thompson A J

Abstract excerpt

BACKGROUND: The biological mechanism underlying the association between IFNL4/IFNL3 polymorphism and peginterferon/ribavirin (PR) response in HCV-1 is thought to involve differential intrahepatic interferon-stimulated gene expression. HCV-3 is more sensitive to PR, but there are no studies of the association between IFNL4 polymorphism, PR treatment response and liver interferon-stimulated gene expression in...

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Source

Identifiers

PMID: 26032235
DOI: 10.1111/apt.13263

Genes

IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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