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Article

Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.

The American journal of pathology - 1 Apr 2016

Ferraris Pauline, Chandra Partha K, Panigrahi Rajesh, Aboulnasr Fatma, Chava Srinivas, Kurt Ramazan, Pawlotsky Jean-Michel, Wilkens Ludwig, Osterlund Pamela, Hartmann Rune, Balart Luis A, Wu Tong, Dash Srikanta

Abstract excerpt

The single nucleotide polymorphism located within the IFNL3 (also known as IL28B) promoter is one of the host factors associated with hepatitis C virus (HCV) clearance by interferon (IFN)-α therapy; however the mechanism remains unknown. We investigated how IL28B gene polymorphism influences HCV clearance with infected primary human hepatocytes, liver biopsies, and hepatoma cell lines. Our study confirms that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26896692
DOI: 10.1016/j.ajpath.2015.11.027
PMCID: PMC5807932

Genes

IFNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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