Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha.

doi:10.3389/fcimb.2021.656393

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Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha.

Frontiers in cellular and infection microbiology - 1 Jan 2021

da Silva Andréa Marques Vieira, Alvarado-Arnez Lucia Elena, Azamor Tamiris, Batista-Silva Leonardo Ribeiro, Leal-Calvo Thyago, Bezerra Ohanna Cavalcanti de Lima, Ribeiro-Alves Marcelo, Kehdy Fernanda de Souza Gomes, Neves Patrícia Cristina da Costa, Bayma Camilla, da Silva Jane, de Souza Alessandro Fonseca, Muller Marcelo, de Andrade Elisabete Ferreira, Andrade Ana Carolina Magalhães, Dos Santos Eliane Matos, Xavier Janaína Reis, Maia Maria De Lourdes De Sousa, Meireles Rolando Páez, Cuni Hugo Nodarse, Sander Guilherme Becker, Picon Paulo Dornelles, Matos Denise C S, Moraes Milton Ozório

Abstract excerpt

Sustained virologic response (SVR) in chronic hepatitis C (CHC) treatment denotes that the host genetics controls the immune response and unequivocally contribute to viral clearance or disease severity. In this context, single nucleotide polymorphisms (SNPs) in the locus of interferon lambda 3 and 4 genes (IFNL3/4) have been important genetic markers of responsiveness to CHC as prognostic markers for the...

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PMID: 34307188
DOI: 10.3389/fcimb.2021.656393
PMCID: PMC8294038

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Source receipt: pubmed, retrieved 7 Sept 2026.

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