Article
Understanding the molecular mechanism(s) of hepatitis C virus (HCV) induced interferon resistance.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2013
Qashqari Hanadi, Al-Mars Amany, Chaudhary Adeel, Abuzenadah Adel, Damanhouri Ghazi, Alqahtani Mohammed, Mahmoud Maged, El Sayed Zaki Maysaa, Fatima Kaneez, Qadri Ishtiaq
Abstract excerpt
Hepatitis C virus (HCV) is one of the foremost causes of chronic liver disease affecting over 300 million globally. HCV contains a positive-stranded RNA of ~9600 nt and is surrounded by the 5' and 3'untranslated regions (UTR). The only successful treatment regimen includes interferon (IFN) and ribavirin. Like many other viruses, HCV has also evolved various mechanisms to circumvent the IFN response by blocking...
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