Article

IFN-λ4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

2020-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Chronic hepatitis C virus (HCV) infection and cirrhosis are major risk factors for developing hepatocellular carcinoma (HCC). Genetic polymorphisms in the IFNL3/IFNL4 locus have been associated both with impaired clearance of HCV and protection from liver fibrosis, an early stage of cirrhosis. Here, we aimed to address the genetic and functional relationships between IFNL3/IFNL4 polymorphisms,...

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Literature Corpus work: 7ddbc440-759e-5f29-83eb-d396b1c8774c
DOI: 10.1101/2020.10.28.359398

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