IFN-λ4: the paradoxical new member of the interferon lambda family.

doi:10.1089/jir.2013.0136

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Article

IFN-λ4: the paradoxical new member of the interferon lambda family.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Nov 2014

O'Brien Thomas R, Prokunina-Olsson Ludmila, Donnelly Raymond P

Abstract excerpt

Interferons (IFNs) are generally considered antiviral cytokines, yet the newly discovered IFN-λ4 is linked with the failure to clear hepatitis C virus (HCV) infection either spontaneously or in response to treatment. IFN-λ4 can be generated only by individuals who carry the IFNL4-ΔG allele (rs368234815), which is the strongest known host factor for predicting clearance of HCV. The ancestral IFNL4-ΔG allele is the...

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PMID: 24786669
DOI: 10.1089/jir.2013.0136
PMCID: PMC4217005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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