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Article

Dynamics of ARF regulation that control senescence and cancer

30 Nov 2016

Abstract excerpt

ARF is an alternative reading frame product of the INK4a/ARF locus, inactivated in numerous human cancers. ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. It functions by sequestering MDM2 (a p53 E3 ligase) in the nucleolus, thus activating p53. Besides MDM2, ARF has numerous other interacting partners that induce either cellular senescence or...

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Identifiers

PMID: 27470213
DOI: 10.5483/bmbrep.2016.49.11.120

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