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Article

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

7 Jul 1998

Abstract excerpt

The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the retinoblastoma protein and p53, respectively. Disruption of this locus by deletions or point mutations is a common event in human cancer, perhaps second only to the loss of p53. Using insect cells infected with baculovirus vectors and NIH 3T3 fibroblasts infected with ARF retrovirus, we...

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Identifiers

PMID: 9653180
DOI: 10.1073/pnas.95.14.8292

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2PMID 9653180Read ↗

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It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer TherapySemantic proximity Read ↗

INK4a/ARF: a multifunctional tumor suppressor locus.Semantic proximity Read ↗

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Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23.Semantic proximity Read ↗

Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.Semantic proximity Read ↗

The ARF tumor suppressor: Structure, functions and status in cancerSemantic proximity Read ↗

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