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The ARF Tumor Suppressor Can Promote the Progression of Some Tumors

1 Dec 2008

Abstract excerpt

p14/p19ARF (ARF) is a tumor suppressor gene that is frequently mutated in human cancer. ARF has multiple tumor suppressor functions, some of which are mediated by signaling to p53. Surprisingly, a significant fraction of human tumors retain persistently high levels of ARF, suggesting that ARF may possess a prosurvival function. We show that ARF protein is markedly up-regulated in cells exposed to nutrient...

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Identifiers

PMID: 19047137
DOI: 10.1158/0008-5472.can-08-2263

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