Article
ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.
Nature communications - 1 Jan 2013
Carlos Ana Rita, Escandell Jose Miguel, Kotsantis Panagiotis, Suwaki Natsuko, Bouwman Peter, Badie Sophie, Folio Cecilia, Benitez Javier, Gomez-Lopez Gonzalo, Pisano David G, Jonkers Jos, Tarsounas Madalena
Abstract excerpt
ARF is a tumour suppressor activated by oncogenic stress, which stabilizes p53. Although p53 is a key component of the response to DNA damage, a similar function for ARF has not been ascribed. Here we show that primary mouse and human cells lacking the tumour suppressor BRCA2 accumulate DNA damage, which triggers checkpoint signalling and ARF activation. Furthermore, senescence induced by Brca2 deletion in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.