Article
ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.
Nature communications - 1 Jan 2013
Carlos Ana Rita, Escandell Jose Miguel, Kotsantis Panagiotis, Suwaki Natsuko, Bouwman Peter, Badie Sophie, Folio Cecilia, Benitez Javier, Gomez-Lopez Gonzalo, Pisano David G, Jonkers Jos, Tarsounas Madalena
Abstract excerpt
ARF is a tumour suppressor activated by oncogenic stress, which stabilizes p53. Although p53 is a key component of the response to DNA damage, a similar function for ARF has not been ascribed. Here we show that primary mouse and human cells lacking the tumour suppressor BRCA2 accumulate DNA damag...
Topics
- Animals
- BRCA2 Protein
- Cell Line
- Cricetinae
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Damage
- Epigenesis, Genetic
- Extracellular Signal-Regulated MAP Kinases
- Fibroblasts
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- HeLa Cells
- Humans