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Article

The Arf/p53 Pathway in Cancer and Aging

1 Aug 2008

Abstract excerpt

Arf and p53 are regarded among the most relevant tumor suppressors based on their ubiquitous and frequent inactivation in human cancer. The Arf/p53 pathway protects cells against several types of damage and this is the basis of its tumor suppressor activity. Interestingly, aging is a process associated with the accumulation of damage derived from chronic stresses of small magnitude. In agreement with its damage...

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PMID: 18676821
DOI: 10.1158/0008-5472.can-07-6851

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