Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.

doi:10.1038/sj.onc.1205371

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.

Oncogene - 2 May 2002

Palmero Ignacio, Murga Matilde, Zubiaga Ana, Serrano Manuel

Abstract excerpt

The ARF tumour suppressor protein (p14(ARF) in human and p19(ARF) in mouse) is a major mediator of the activation of p53 in response to oncogenic stress. Little is known about the signalling pathways connecting oncogenic stimuli to the activation of ARF. Regulation of ARF occurs primarily at the transcriptional level and several modulators of ARF transcription have been identified. Notably, ectopic expression of...

Topics

Adenovirus E1A Proteins
Animals
Apoptosis
Cell Cycle Proteins
Cell Transformation, Neoplastic
Cell Transformation, Viral
Cells, Cultured
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16
DNA Damage
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

E2F Transcription Factors

E2F1 Transcription Factor

E2F2 Transcription Factor

Fibroblasts

Gamma Rays

Genes, ras

Genetic Vectors

Source

Open in PubMed

Identifiers

PMID: 12082524
DOI: 10.1038/sj.onc.1205371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12082524-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.PMID 12082524Read ↗

Dynamics of ARF regulation that control senescence and cancerSemantic proximity Read ↗

Post-Translational Regulation of ARF: Perspective in CancerSemantic proximity Read ↗

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.Semantic proximity Read ↗

Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell Senescence FactorsSemantic proximity Read ↗

p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism.Semantic proximity Read ↗

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.Semantic proximity Read ↗

Non-Canonical Functions of the ARF Tumor Suppressor in Development and TumorigenesisSemantic proximity Read ↗

E2F-Dependent Induction of p14ARF During Cell Cycle Re-entry in Human T CellsSemantic proximity Read ↗

The ARF Tumor Suppressor Can Promote the Progression of Some TumorsSemantic proximity Read ↗

The INK4a/ARF locus in murine tumorigenesis.Semantic proximity Read ↗

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14 <sup>ARF</sup> Tumor SuppressorSemantic proximity Read ↗

Regulatory Network of ARF in Cancer Development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.