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Article

p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism.

Cell cycle (Georgetown, Tex.) - 15 Jul 2007

Rizos Helen, Scurr Lyndee L, Irvine Mal, Alling Nikki J, Kefford Richard F

Abstract excerpt

Alterations in the ARF tumor suppressor protein (also known as p14ARF in humans and p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to melanoma, pancreatic cancer and nervous system tumors. ARF proteins interact with the E2F-1, -2 and -3 transcription activators to inhibit their transcriptional activity and induce their degradation via the 26S proteasome pathway. The impact...

Topics

Animals
Cell Cycle
Cell Line, Tumor
E2F1 Transcription Factor
Genetic Predisposition to Disease
Humans
Mice
Signal Transduction
Tumor Suppressor Protein p14ARF
Tumor Suppressor Protein p53
Ubiquitin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ubiquitination

Source

Identifiers

PMID: 17630509
DOI: 10.4161/cc.6.14.4428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17630509-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism.PMID 17630509Read ↗

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