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Article

p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism.

Cell cycle (Georgetown, Tex.) - 15 Jul 2007

Rizos Helen, Scurr Lyndee L, Irvine Mal, Alling Nikki J, Kefford Richard F

Abstract excerpt

Alterations in the ARF tumor suppressor protein (also known as p14ARF in humans and p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to melanoma, pancreatic cancer and nervous system tumors. ARF proteins interact with the E2F-1, -2 and -3 transcription activators to inhibit their transcriptional activity and induce their degradation via the 26S proteasome pathway. The impact...

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Source

Identifiers

PMID: 17630509
DOI: 10.4161/cc.6.14.4428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism.PMID 17630509Read ↗

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